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One action is to interfere with tyrosinase, an enzyme that helps make melanin (skin pigment)

Methotrexate does not increase the risk of liver fibrosis in patients with rheumatoid arthritis: assessment by ultrasound elastography (ARFI-MetRA study)

An increase in respiratory drive elicited by GSGee may decrease the number of sighs and decrease the number of apneas, but that would not be defined definitively by a change in the rejection index since this index also includes sniffs and changes in respiratory waveforms due to behavioral movements 87 , although it must be noted that the fentanyl-treated rats (those that received vehicle or GSHee) were basically immobile throughout the ventilatory study

Cytostatic agents, particularly platinum-based drugs such as topotecan and cisplatin, have been linked to the induction of eryptosis, thereby worsening anemia [392, 393]