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Some use herbal shisha instead of tobacco, but those come with their own risks

Participants younger than 60 years (n = 285,022), without ethnic background information (n = 1182) or not White British (n = 17,400), with missing APOE genotype information (n = 5324) or 1 allele (n = 25), with unmatched self-reported sex and genetic sex (n = 121) and excessive relatives (n = 88), and with dementia at baseline or prior to recruitment (n = 145) were excluded (Supplementary Fig

Stepping up

Again, note that the smoking-cessation program alternative is made available without the participant having to demonstrate that it would be unreasonably difficult due to a medical condition, or medically inadvisable, to stop tobacco use (see Example 6