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740 Activity assays reveal that as expected, Zn II binding to site 2 inhibits turnover by QueD2, which suggests that the active site 1 may well be conformationally plastic or dynamically heterogeneous and must fold to accommodate substrate, in striking contrast to the housekeeping enzyme QueD

Brain coronal blocks were embedded in paraffin, sectioned at 4 m, stained with H&E and evaluated by light microscopy using neuropathological scoring

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