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Subjects who did not complete the sampling schedule of one or more study periods were included in the PK analysis for only the PK parameters that were judged not to be affected by the missing sample(s)

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But instead of a vein of gold, they found only an impenetrable mass of rocks and boulders

The fibres (4) of the filter tow are arranged to have a particular curvature which is similar to the curvature of the filter shape where it meets the tobacco rod, and this allows the flow of the smoke stream to flow from the centre towards the outer edges of the filter (la), increasing the overall rate of filtration and the uniformity of filtration over the axial cross section compared with a filter in which the fibres have no such curvature