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TB-500 TB-500 is a synthetic peptide derived from thymosin beta-4

AT 2 receptor-deficient mice increased anxiety-like behaviors, which can be reversed by captopril, and show no depression-like behaviors compared to wild-type mice, providing a theoretical basis for ACEIs for the treatment of emotional disorders (35)

Specific Adverse Effects Reported in Clinical Trials While the overall safety profile was excellent, clinical trials documented all adverse events regardless of severity or causality