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However, OncoLink notes that smoking a pipe still puts you at a greater risk than nonsmokers for developing a number of serious diseases, including: Oral (mouth, tongue and lip) cancer Esophageal cancer Voice box (larynx) cancer Cancer of the nasal cavity Lung cancer Liver cancer Bladder cancer Lung disease Heart disease Stroke According to the American Medical Association (AMA), you also run a greater risk of having respiratory tract infections when you smoke tobacco -- including COVID-19