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In addition, the cytoprotection was independent of the antioxidant status of the catalase and glutathione peroxidase enzymes, suggesting a direct interaction between creatine and oxidant and/or free radicals

6 Obesity-related hypothalamic inflammation and proinflammatory cytokine production can lead to suppression of leptin signaling and failure to feel the sensation of being full, known as leptin resistance

That consistent neuroprotective effect appeared in all brain areas (Figure 12)

Vitamin D acts as a transcriptional regulator for eNOS, leading to enhanced production of NO, which is known as the most powerful vasodilator in the vasculature [141]