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Symptoms of deficiency can vary from person to person, but may include impaired brain function, tiredness and lack of energy, breathlessness and fatigue, headaches, pale skin, heart palpitations, loss of appetite and weight loss, anxiety and depression

Without those findings, the elevation is better weighed against the broader metabolic picture and any comorbidities

The phenotypic outcome is a shift toward higher energy expenditure and improved adipose/lipid profiles without the catabolic loss of lean tissue commonly seen with severe caloric restriction