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Several milligrams of nicotine are present in each gram of tobacco, and nicotine reaches around 0.2 micromolar concentrations in the blood of smokers, sufficient to cause nAChR responses ( As the major pharmacologically active component of tobacco smoke, nicotine has also been investigated to see whether it can cause other effects, reported from smoking, such as relief from anxiety and depression, improved concentration and symptom control in Schizophrenia, Parkinsons Disease, Attention Deficit Hyperactivity Disorder, and Alzheimers Disease (Mihailescu and Drucker-Colin, 2000

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