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Abbreviations CNS Central nervous system SCI Spinal cord injury TBI Traumatic brain injury L-ROS Reactive oxygen species L-OOH Lipid hydroperoxides L-OH lipid alcohols GSH Glutathione CoA Coenzyme A OH Soluble hydroxyl RO Lipid alkoxy RSL3 (1S,3R)-RSL3 Hb Hemoglobin TFR1 Transferrin receptor 1 DMT1 Divalent metal transporter 1 LIP Labile iron pool PUFA Polyunsaturated fatty acid ACSL4 Acyl-CoA synthetase long-chain family member 4 LPCAT3 Lysophosphatidylcholine acyl transferase 3 PLs Phospholipids BSO Buthionine sulfoximine GPX4 Glutathione peroxidase 4 DPI2 Diverse pharmacological inhibitor-2 NAPQI N-acetyl -p-benzoquinone imine ROOH Reduce organic peroxide H 2 O 2 Free hydrogen peroxide L- O- Alkoxy radicals Tf Transferrin TFR1 Transferrin receptor 1 STEAP3 Six-transmembrane protein prostate 3 DMT1 Divalent metal transporter 1 PCBP1 Poly(rC)-binding protein AA Catalyses arachidonic acid AdA Adrenic acid PE Phosphatidylethanolamines LOXs Lipoxygenase 15-LOX 15-lipoxygenase TEM Transmission electron microscopy IREB2 Iron-responsive element-binding protein 2 ACSF2 Acyl-CoA synthetase family member 2 DFO Deferoxamine PAC Proanthocyanidin ALOX15B Arachidonate 15-Lipoxygenase Type B TBARS Thiobarbituric acid reactive substances Nrf2 Nuclear factor-erythroid 2-related factor 2 HO-1 Heme oxygenase-1 GSSG Oxidized glutathione Lipro-1 Liproxstatin-1 IREB2 Iron Responsive Element Binding Protein 2 PTGS2 Prostaglandin-endoperoxide synthase 2 RPL8 Ribosomal Protein L8 CCI Cortical impact injury MDA Malondialdehyde AA/AdA-PE Arachidonic/adrenic acid-containing-phosphatidylethanolamine COX-2 Cyclooxygenase-2 IRI Ischemia-reperfusion injury MLKL Mixed lineage kinase domain-like pseudokinase

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PMID: 35410439