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Wang C, Huang L, Li R, Wang Y, Wu X, Shang D (2021a) Synergistic therapy of doxorubicin with cationic anticancer peptide L-K6 reverses multidrug resistance in MCF-7/ADR cancer cells in vitro via P-glycoprotein inhibition

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Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months

Peptides that target the gut-skin connection BPC-157 is the most studied peptide for gut barrier protection