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As the WL achieved with the novel obesity pharmacotherapies approaches that of bariatric surgery, we will need to assess whether long-term complications observed after bariatric surgery such as increased risk of osteoporosis, fractures, macro- and micronutrient deficiencies as well as self-harm behaviours will also be present with pharmacotherapy [112, 113]

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Total through week 12: 18 mg

Ensemble Modelling When we endeavoured to find the Michaelis Menten parameters for use in the kinetic modelling of the glutathione recycling system, we found the literature to be lacking in suitable parameters for the chosen genes (in particular for the glutathione peroxidase)