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TECHNICAL DESCRIPTION A new combined filter has been developed that includes up to three different types of membranes, each with specific characteristics, where the location of these is essential to achieve a significant improvement in the elimination of tars and toxic compounds in tobacco smoke

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Assay accuracy and precision accuracy were validated on LC-MS/MS by repeated sample quantification by preparing five individual samples of reaction matrix containing 1 ppm cotinine, COX, or 3HC standard, processing them for LC-MS/MS, and immediately measuring cotinine, COX, or 3HC concentrations for each standard sample as compared to individually prepared standard curves all measured by LC-MS/MS as previously described