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When those outcomes were not reported and/or when it was not possible to observe the exclusive effects of coffee enema (e.g., mixed interventions), the studies were excluded

doi: 10.1136/gutjnl-2019-318747 10

1986 Nov-Dec;7(6):1165-87

Sadly, a study published in late 2014 found that nearly half of patients at high risk for the development of acute kidney injury concurrently used NSAIDs, and that risk for [chronic kidney disease] and [acute kidney injury] is not routinely assessed among those for whom NSAIDs are prescribed (Jang 2014)