In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)
References Alzoubi KH, Mayyas FA, Khabour OF, Bani Salama FM, Alhashimi FH, Mhaidat NM (2016) Chronic melatonin treatment prevents memory impairment induced by chronic sleep deprivation
the copper in GHK-Cu could plausibly interact with the other peptides in solution
In: ColeLAButlerSA, editors