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Finally, further significant efforts towards practical therapeutics led to FDA-approved ADCs: gemtuzumab ozogamicin (Mylotarg ) in 2000 for CD33-positive acute myelogenous leukemia (Sievers et al., 2001), brentuximab vedotin (Adcetris ) in 2011 for CD30-positive relapsed or refractory Hodgkins lymphoma and systemic anaplastic large cell lymphoma (Younes et al., 2010), and trastuzumab emtansine (Kadcyla ) in 2013 for HER2-positive breast cancer (LoRusso et al., 2011

Induction of phenylalanine ammonia-lyase and lipoxygenase in cotton seedlings by mechanical wounding and aphid infestation

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