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Indeed, cell-mediated immunity requires that protein antigens be first degraded in the endocytic vesicles of APCs (eg, macrophages, dendritic cells), so that the smaller peptides can be presented on the cell surface by the major histocompatibility complex to activate proliferation of antigen-specific T cells

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Its unique Ec domain provides a mechanistically distinct signal from systemic IGF-1 analogues, allowing researchers to study the local muscle precursor cell response independently of systemic anabolic signalling