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Visceral obesity, metabolic syndrome, insulin resistance and cancer
TP53 also influences ferroptosis sensitivity through other mechanisms, such as downregulating VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1) in vitamin K metabolism [151] and inducing SAT1 (spermidine/spermine N1-acetyltransferase 1), an enzyme in polyamine catabolism that produces ROS [152]
2012 PubMed Schandelmaier S, Briel M, Saccilotto R, Olu KK, Arpagaus A, Hemkens LG, Nordmann AJ