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Mouse lymphoma model and tumor xenografts The previously described mouse model of Burkitt lymphoma C57BL/6N-Tg(IGL-MYC)3Hm (-MYC mice) [35] was obtained from the NCI mouse repository (Strain code 01XA7), backcrossed to C57BL/6J for more than 10 generations, and maintained in heterozygosity in a C57BL/6 J background

Domain Structure and Signaling Components of HGF-MET Pair Hepatocyte growth factor is produced and secreted as pro-HGF, representing the inactive precursor, and then activated by proteolytic processing in the extracellular milieu (Naldini et al., 1992)

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This imbalance disallows reactive intermediate detoxification by the cell biological systems