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Because this also breaks naturally occurring disulfide bonds within the antibodies, the team next had to reoxidise their antibodies to repair them

For example, recent chemical screens have identified small molecules that bind to CRY proteins and modulate their ubiquitin-mediated degradation, offering a potential strategy for resetting of the clock (Solt et al., 2012

doi: 10.3390/molecules28114548 217 BarakatHAljutailyTAlmujaydilMSAlgheshairyRMAlhomaidRMAlmutairiASet al