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The Nrf2 protein then translocates into the cell nucleus, where it binds to the Antioxidant Response Element (ARE) on the DNA

Varinelli L, Guaglio M, Brich S, Zanutto S, Belfiore A, Zanardi F, Iannelli F, Oldani A, Costa E, Chighizola M, Lorenc E, Minardi SP, Fortuzzi S, Filugelli M, Garzone G, Pisati F, Vecchi M, Pruneri G, Kusamura S, Baratti D, Cattaneo L, Parazzoli D, Podesta A, Milione M, Deraco M, Pierotti MA, Gariboldi M (2023) Decellularized extracellular matrix as scaffold for cancer organoid cultures of colorectal peritoneal metastases

7 of 12 reported subjective improvement at six-month follow-up.5 A separate 2025 pilot evaluated intravenous infusion at 10 mg and 20 mg in two adults with no adverse effects on organ biomarkersbut two subjects do not constitute a trial

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