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Lastly, although vesicles have been reported to be characteristic of allergic reactions,6 they are also found in up to 9% of irritant reactions, according to some studies, possibly owing to a spongiosis phenomenon or irritant cytolysis that would be visible both in histology12 and in optical coherence tomography.13 Dermoscopy in Clinically Doubtful Reactions According to the ESCD, doubtful reactions are those that present with faint erythema only, which cannot be classified as irritant, since it is not predominantly perifollicular

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