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They've been through rigorous clinical trials

[5] Several studies suggest a dose-response relationship, where higher titers of thyroid antibodies correlate with: Greater likelihood of menstrual irregularities Earlier onset of ovarian dysfunction More pronounced follicular depletion In one study, women with high anti-thyroperoxidase antibodies (TPOAb) levels were significantly more likely to have reduced ovarian reserve (e.g

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525,526 However, in a randomized controlled trial involving 244 patients with PDPN, 7 treated with venlafaxine developed clinically significant electrocardiogram changes during treatment, making it less preferred in patients with cardiovascular conditions