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In addition to the increased expression of macrophages, NAD+ also exerts anti-inflammatory effects during an infectious process

However, a direct reduction in the size of certain hypertrophic cardiomyocytes and replication of other size-reduced hypertrophic cardiomyocytes contribute significantly to the regression of copper-deficient cardiac hypertrophy, resulting in the normalization of the size and number of cardiomyocytes in the heart (113)

This dual-action approach is of interest because it may influence appetite signalling, calorie utilisation, and metabolic rate at the same timesomething single-pathway compounds may not achieve