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Metabolic pathway requiring 5-deoxyadenosylcobalamin The figure illustrates the metabolic pathway for the vitamin B 12 -dependent enzyme L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA into succinyl-CoA for entry into the citric acid cycle

Poor vitamin B 12 status has been linked to increased risk of breast cancer in some, but not all, observational studies

Therefore, the development of this vaccine in clinical trials could be more complicated than in in vivo experiment, given the diverse physiological functions of GPNMB in normal cells

Taking in extra B12 through injections or supplements when your levels are already normal will not provide additional benefits