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In all models, the following fixed covariates were entered: assigned treatment (investigational product or placebo), baseline measurement of the outcome of interest, visit (day 14 1 day or day 28 1 day), visit in interaction with treatment, period (period 1 or period 2), sex and, for MIDT outcomes, incentive level

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In addition to exploring the potential mechanisms, this article also reviews various treatments to regulate the balance of Th17/Treg, including conventional drug treatment, traditional Chinese medicine compounds, probiotics and emerging therapies

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