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demonstrated that compared with sham-operated controls, 5/6 NX rats with hypertension exhibited an increased abundance of Bacteroides and a decreased abundance of Lactobacillus , which correlated with urinary protein excretion [152]

Approaches such as intrathecal, intracerebroventricular, and intraparenchymal injections, as well as transient BBB disruption, have been employed to deliver drugs with limited CNS bioavailability (Rezaee et al., 2025)

While copper peptides are generally well-tolerated, individual reactions vary

The capacity of GPX4 to influence cell viability through several pathways highlights its potential as a promising therapeutic target for malignancies