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Furthermore, ROS contribute to the apoptotic pathway mediated by Trx-ASK1 and p38 in microglia, as Trx is an oxidative stress-sensitive marker that can trigger this pathway to regulate cell death (Noguchi et al., 2008

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Thus, GSH supplementation in the DG sub-group of elderly diabetic patients over a period of 6 months led to a significant increase in the erythrocyte GSH, GSSG, and FPI and a decrease in HbA1c and 8-OHdG levels (Figure S2), suggesting that the elderly diabetic population responds better to GSH supplementation in conjunction with anti-diabetic therapy