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& Tanrattanakorn, S

Occasionally, signs of acute toxicity may be absent for 1248 hours following administration, after which a critical phase may develop, characterised by pulmonary oedema, vasomotor collapse, cyanosis, acute hepatic failure, coma, and death of the animal

Another drug explored as an AD therapeutic is Axitinib, which is a small molecule tyrosine kinase inhibitor that targets vascular endothelial grown factor receptors and is used as an anticancer drug

The FDAs approval was backed by data from the Phase III KEYNOTE-A18 study, where Keytruda plus CRT reduced the risk of disease progression or death by 41% versus placebo plus CRT, Merck reported