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Persistent oxidative stress and induction of nuclear-factor-erythroid 2related-factor 2 (NRF2) antioxidant response in KO livers EtOH feeding decreased GSH levels specifically in the mitochondrial pool of livers of WT mice (Fig

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N Engl J Med (2015) 373:24846

discovered that insomnia is associated with significant changes in the structure and function of gut microbiota, showing reduced diversity (both -diversity and -diversity) and altered microbial interactions in individuals with insomnia compared to healthy controls [213]