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doi:10.1016/j.brainres.2021.147277

Given the more direct drug delivery route, intranasally delivered drugs have the potential to be more potent, work more quickly, be better targeted, produce less side effects and be more effective overall

CBS and CSE are located in the cytosol of cells, whereas 3MST primarily resides in and generates H 2 S in mitochondria

Further analysis revealed that STEAP3 expression at both the mRNA and protein levels was significantly lower in H3K18R-treated cells compared to the wild-type (WT) group, confirming that reduced H3K18la levels decreased STEAP3 expression (Supplementary Fig