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Therefore, a deep understanding and precise regulation of the protein corona is one of the core challenges in balancing the targeting efficiency of liver-targeting nanocarriers and their immunocompatibility, ultimately achieving their successful clinical translation

Parkin is a ubiquitously transcribed protein that has been linked to the endoplasmic reticulum, synaptic vesicles, Golgi apparatus, and mitochondria in intracellular investigations (Shimura et al., 1999

Immunogenicity The ability of a foreign substance, such as a viral or non-viral vector, to provoke an undesirable immune response, which can lead to reduced efficacy of the drug, allergic reactions or other adverse reactions