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The LR3 variant includes modifications that reduce binding to IGF-binding proteins, allowing the peptide to remain active on cell receptors for a longer period during experimental procedures

These post-translational modifications enhance the aggregation propensity of -syn and promote iron reduction cycle, forming a self-amplifying positive feedback loop ( 3.2 Regulation of glial cells on iron metabolism in PD Iron toxicity has become an important pathogenesis of Parkinsons disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 101.Stachon T., Kolev K., Flask Z., Seitz B., Langenbucher A., Szentmry N

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