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In terms of adverse effects, statins reduced stem cells osteogenic and chondrogenic differentiation potential and enhanced cell senescence and apoptosis, as shown through p16 (CDKN2A), p53 (TP53) and caspase 3, 8 and 9 upregulation

This study demonstrates through twin studies that genetic factors account for the majority of disc degeneration variability

The addition of GSH or expression of Grxs 1 and 2 significantly improves mutant SOD1 solubility in cell culture, whereas reducing the levels of intracellular GSH decreases SOD1 solubility, suggesting that GSH reduction promotes the aggregation of mutant SOD1 (Guareschi et al., 2012)