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This work was supported by the Fundamental Research Program of Shanxi Province (202403021212266) and the Changzhi Medical College Research Initiation Funds for PhD (BS202317)

Our data (supplementary Fig

The 2024 Tsai split-face RCT in Journal of Cosmetic Dermatology demonstrated significant melasma severity reduction with combined microneedling radiofrequency plus cysteamine

Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing