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[17] Physiologic B12 requirements increase during gestation, and parenteral cyanocobalamin is considered appropriate when dietary intake or intestinal absorption is inadequate

Mass Spectrometry High-resolution mass spectrometric analyses (UPLC-ESI-TOF MS) were performed on a Waters Synapt G2-S HDMS spectrometer coupled to an Acquity UPLC core system (Waters, Milford, MA, USA) consisting of a binary solvent manager, sample manager and a 2 150 mm, 1.8 m, HSS T3 C18 column (Waters, Manchester, UK)