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After a 72-h incubation, 15 L of 5-mg/mL CellTiter 96 Aqueous One Solution (Promega, Madison, WI, USA) was added to each well and incubated for 1 h

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Adaptogens and Adaptive Stress Response The term adaptogen is primarily associated with the notion of adaptability introduced by George Canguilhem in 1943 [185], who defined adaptability as the ability of an organism to alter itself or its responses to the changed environment or circumstances and assumed that adaptability shows the ability to learn and improve from experiencerepeated mild exposure or low doses of stress result in the increased resistance of cells and organisms to subsequent stress exposure, resulting in an adaptation that favors survival