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These mice are a transgenic model overexpressing three genes containing AD-associated mutations, one each for APPsw, PS-1, and MAPT (Oddo et al., 2003)

Perhaps most amazingly, the mices behavior changed, too frail mice seemed to grow younger and began to explore, exercise, and respond to physical stimuli just like healthy young mice did

coli under the control of various global regulators such as OxyR and SoxR