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Molecular analyses showed that CO23RFLC had acquired a marked increased expression of the MDR1 gene encoding for an efflux pump protein mainly responsible for the drug-resistance, due to a mutation in the transcription factor gene MRR1 [16] whereas CO23RFK had a homozygous mutation (S645Y substitution) in the FSK1 gene, responsible for the synthesis of glucan [17]

This work breaks new ground in proposing an alternative user-friendly strategy that can significantly enhance topical delivery inside human nose

Aceleracin de la cicatrizacin: El GHK-Cu acelera significativamente la cicatrizacin de las heridas cutneas

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Nabekura T., Koizumi Y., Nakao M., Tomohiro M., Inomata M., Ito Y