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In-Hospital Mortality After Lumbar Fusion is Rare But Occurs Early: A Nationwide Analysis of Risk Factors, 2016-2022

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5-Amino-1MQ acts as a competitive inhibitor with respect to the nicotinamide substrate (submicromolar IC50), increasing the intracellular nicotinamide available for NAD+ salvage via NAMPT - which is then studied for downstream effects on NAD+-dependent sirtuins and mitochondrial function