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28, 30 Caution is advised when prescribing colchicine to patients who are taking medicines that inhibit the CYP3A4 enzyme and/or P-glycoprotein, e.g

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To qualify for this procedure, your body mass index (BMI) must be 40 or greater, or between 30 and 40 with other weight-related medical conditions

A reduction of the N-terminal peptide bond of 25 , with the ambition to achieve a compound even more resistant to proteolytic cleavage, provided 26 ( 26 displays a Ki value in the micromolar range in sharp contrast to what could be expected considering the results obtained after reduction of Ang IV or Nle-Ang IV, cf