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In the context of recent findings that perception of risk plays a key role in predicting substance use, and that perception of risk associated with cannabis use has declined steadily along with legalization, these findings were somewhat of a surprise

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Evidence from industry documents While tobacco companies used to create advertising campaigns directly for children, using whimsical packaging and cartoon characters, such direct messaging was eventually ruled illegal

Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells