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These mechanisms are not fully understood but include central nervous system carbohydrate reduction and glycolysis inhibition, changes in neuronal excitability mediated by ATP-sensitive potassium channels through alterations in mitochondrial function, inhibition of the mammalian target of rapamycin (mTOR) pathway, and inhibition of glutamatergic excitatory synaptic transmission [72]

[5] Researchers posit that the peptide is the first ghrelin mimetic with a selectivity for GH release similar to that displayed by GHRH

Spontaneous O 2 dismutation or catalysis by superoxide dismutase (SOD) action produces hydrogen peroxide (H 2 O 2 ) [22]

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