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Potential Side Effects: Generally well-tolerated, but possible side effects may include mild irritation at the injection site or allergic reactions

ReCePI is powered on an expected 30% incidence of AKI in high-risk complex cardiac surgery subjects based on the incidence of renal impairment in two prior studies performed by the Sponsor [8, 24]

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Reduced tumor burden and decreased expression of metastasis markers, p-IGF1R and p-ERK1/2, as well as changes in IGF system gene expression in lungs of IGF1R-deficient mice To evaluate the effect of IGF1R depletion on LLC metastasis, tumor burden, metastasis markers, p-IGF1R, p-ERK1/2 and IGF system gene expression were assessed in lungs of IGF1R-deficient ( CreERT2 ) mice vs