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i Yan Jiu 48 , 158164 (2023)

KPV is a powerful chain terminal tripeptide of alpha-MSH, which is produced by melanotrope cells in the intermediate lobe of the pituitary gland

In the CT-like conformation, the bypass motif becomes unstructured, and residues (S21-P28) are not well resolved, suggesting this flexible segment is exposed to the solvent environment