Hepatic effects that are considered adverse include death, abnormal clinical chemistry parameters, obvious functional organ impairment, DNA and mitochondrial alteration, glutathione depletion, hepatocyte necrosis, enhanced replicative DNA synthesis, generation of reactive oxygen species, and increased peroxisome proliferation (in rodents) (Williams and Iatropoulos 2002)
VKORC1L1 overexpression significantly attenuated tumor growth suppression in p53 wild-type tumors but not in p53-null tumors, suggesting a new pathway for p53-controlled ferroptosis and tumor growth inhibition mediated by vitamin K metabolism modulation
But the consequences of using a suboptimal topical are generally limited to skin irritation and wasted money rather than systemic harm
This safe and effective treatment typically requires multiple sessions (6-8 weekly treatments) for optimal results, often paired with oral glutathione supplements to maximize benefits