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[DOI] [PubMed] [Google Scholar] 70.Wielosz E., Borys O., Zychowska I., Majdan M

In this experiment, we controlled that animals from Nrf2 +/+ litters were responsive to DMF in a way similar to that reported earlier in standard Sprague-Dawley rats

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That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed