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These changes have been associated with increased intestinal permeability, elevated systemic endotoxin levels, and immune dysregulation, all of which may contribute to the development and progression of thyroid dysfunction (Miquel et al., 2013

162,163 The pharmacological basis of their action is increasingly being elucidated through both in vitro and in vivo experimental models, especially in conditions like IBS, peptic ulcers, GERD, and IBD, such as Crohns disease and ulcerative colitis

More oxygen supply causes delay in the onset of muscle fatigue in sportive performance (98) and leads to enhanced energy generation in the form of ATP through the aerobic metabolic pathways