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The telomerase enzyme is composed of two subunits, hTERT and hTR , together, they are responsible for the synthesis of telomeric DNA

This led to the hypothesis that the CG-rich and CG-poor regulatory elements undergo distinct modes of epigenetic regulation (Meissner et al., 2008

For example, NAD+-dependent enzymes include the sirtuins (SIRT1-7), a family of protein deacetylases involved in gene expression, stress responses, and metabolic regulation, as well as poly(ADP-ribose) polymerases (PARPs) that assist in DNA repair

Nausea is a common side effect, especially in the early stages of treatment or following dose increases