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Side Effects, Risks, and Safety Considerations The most common side effects are gastrointestinal nausea, vomiting, and diarrhoea with more serious risks including pancreatitis, gallbladder disease, and elevated resting heart rate

[174] A 2021 report by the Healthcare Cost and Utilization Project on the most frequent principal diagnoses among non-maternal, non-neonatal inpatient stays using the 2018 National Inpatient Sample revealed septicemia as the most frequent principal diagnosis with over 2.2 million hospital stays

That is to say that environmental pressures such as acute inflammation and ischemia do increase transmucosal transport of bacteria and bacterial products in humans, but not likely by the paracellular route

This is why starting 4-6 weeks before your challenging season is so important